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High renal resistive index in hypertensive patients is also associated with serum homocysteine level

Şakir Özgür Keşkek1, Yavuz Çinar, Sinan Kirim

  • 1Department of Internal Medicine, Numune Training and Research Hospital, Yüreğir, Adana, 01240, Turkey, drkeskek@yahoo.com.

Clinical and Experimental Nephrology
|November 7, 2014
PubMed

Insights

Newly diagnosed hypertension is linked to higher homocysteine levels and renal resistive index. Elevated homocysteine is associated with hypertension and correlates with renal resistive index, indicating a potential marker for cardiovascular risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Hypertension, elevated homocysteine, and increased renal resistive index are risk factors for atherosclerosis and cardiovascular diseases.
  • Understanding the interplay between these factors is crucial for managing hypertension-related complications.

Purpose of the Study:

  • To investigate the association between serum homocysteine levels and renal resistive index in patients newly diagnosed with hypertension.

Main Methods:

  • A case-control study included 221 subjects: 116 with newly diagnosed hypertension and 105 healthy controls.
  • Measurements included renal resistive index, serum homocysteine, insulin concentrations, and blood pressure.

Main Results:

  • Hypertensive patients exhibited higher renal resistive index, serum homocysteine, and insulin levels compared to controls (p=0.006, p<0.001, respectively).
  • Serum homocysteine levels were significantly associated with hypertension (OR 9.5, p<0.001).
  • Both homocysteine and insulin levels positively correlated with renal resistive index (r=0.372, p=0.001 and r=0.392, p<0.001, respectively).

Conclusions:

  • A high renal resistive index in hypertensive patients is associated with elevated homocysteine levels.
  • Homocysteine may serve as a biomarker for renal vascular changes in hypertension.
Abstract

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