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ROS1 gene rearrangement and copy number gain in non-small cell lung cancer

Yan Jin1, Ping-Li Sun, Hyojin Kim

  • 1Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, 463-707, South Korea.

Virchows Archiv : an International Journal of Pathology
|November 7, 2014
PubMed

Insights

ROS1 gene rearrangement occurs in 0.8% of non-small cell lung cancer (NSCLC). ROS1 gene copy number gain (CNG) is linked to poorer survival, suggesting it

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • ROS1 rearrangements are potential oncogenic drivers in non-small cell lung cancer (NSCLC).
  • ALK inhibitors show efficacy against ROS1-rearranged tumors, necessitating further investigation into ROS1 alterations.

Observation:

  • This study investigated ROS1 gene rearrangement prevalence and copy number gain (CNG) implications in NSCLC.
  • Fluorescent in situ hybridization and immunohistochemistry were employed to analyze ROS1 status.
  • ROS1 rearrangement was identified in 0.8% of NSCLC patients, predominantly in female, never-smokers with adenocarcinoma.

Findings:

  • ROS1 gene copy number gain (CNG) was observed in 4.8% of NSCLC cases.
  • ROS1 gene CNG significantly correlated with shorter disease-free survival (DFS) and overall survival (OS).
  • Multivariate analysis confirmed ROS1 gene CNG as an independent poor prognostic factor for DFS and OS.

Implications:

  • ROS1 gene rearrangement is a rare but significant finding in NSCLC.
  • ROS1 gene CNG serves as a crucial independent prognostic biomarker in NSCLC.
  • These findings may inform future therapeutic strategies targeting ROS1 in NSCLC patients.

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