Low coherence interferometry approach for aiding fine needle aspiration biopsies
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Ernest W Chang1, Joseph Gardecki2, Martha Pitman3
1Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.
Journal of Biomedical Optics
|November 7, 2014
Abstract:
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.
