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Related Experiment Videos

Lisinopril for severe congestive heart failure.

B F Uretsky1, J A Shaver, C S Liang

  • 1University of Pittsburgh School of Medicine, Pennsylvania.

The American Journal of Cardiology
|February 21, 1989
PubMed
Summary

Lisinopril, an angiotensin-converting enzyme inhibitor, demonstrated significant hemodynamic improvements in patients, including increased cardiac index and reduced pressures. Long-term use showed sustained effects and good tolerability with reversible renal effects in some.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angiotensin-converting enzyme (ACE) inhibitors are crucial in cardiovascular disease management.
  • Lisinopril is a potent ACE inhibitor with a long duration of action.

Purpose of the Study:

  • To evaluate the hemodynamic effects of lisinopril in patients.
  • To determine the dose-response relationship and long-term tolerability of lisinopril.

Main Methods:

  • Hemodynamic assessment in 55 patients receiving 2.5, 5, and 10 mg of lisinopril.
  • Follow-up of 47 patients for 3 months to assess functional capacity, symptoms, and renal function.

Main Results:

  • Significant increases in cardiac index and reductions in pulmonary artery wedge, right atrial, pulmonary arterial, and systemic arterial pressures were observed.

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  • Dose-dependent effects were noted, with most parameters showing significant changes at 24 hours.
  • Sustained hemodynamic effects, improved functional capacity, and acceptable tolerability were observed over 3 months, with reversible renal dysfunction in 26%.

    • Conclusions:

    • Lisinopril exhibits long-lasting hemodynamic benefits.
    • A dose-response relationship for lisinopril's hemodynamic effects can be established.
    • Lisinopril demonstrates a favorable long-term safety and tolerability profile.