Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Meiosis I01:49

Meiosis I

222.8K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
222.8K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.8K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.8K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

4.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
4.1K
Nondisjunction01:29

Nondisjunction

84.3K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
84.3K
Nondisjunction01:21

Nondisjunction

6.0K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
6.0K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

5.1K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orthodontists' Perceptions, Attitudes, and Adoption of Artificial Intelligence: A Scoping Review.

Dentistry journalยท2026
Same author

Orthodontic and Maxillofacial Surgery Treatment in Achondroplasia for Orofacial Alterations: A Systematic Review and Preliminary Age-Stratified Guidelines.

Orthodontics & craniofacial researchยท2026
Same author

Genetic Determinants of Primary Failure of Eruption: A Comprehensive Review of PTH1R Variants.

Genesยท2026
Same author

Present and Future of the Use of Artificial Intelligence in Orthodontics.

Bioengineering (Basel, Switzerland)ยท2026
Same author

Implant Surface Characteristics and Peri-Implant Outcomes: A Systematic Review of Clinical and Microbiological Evidence.

Bioengineering (Basel, Switzerland)ยท2026
Same author

Genetic Testing in Periodontitis: A Narrative Review on Current Applications, Limitations, and Future Perspectives.

Genesยท2025

Related Experiment Video

Updated: Apr 21, 2026

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
07:11

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants

Published on: May 23, 2020

8.1K

Bilateral condylar resorption in down syndrome.

Cristina Grippaudo1, Francesca Romana Grippaudo, Tito Matteo Marianetti

  • 1From the Catholic University of Rome, Rome, Italy.

The Journal of Craniofacial Surgery
|November 8, 2014
PubMed
Summary

Idiopathic condylar resorption, a rare disease, can present asymptomatically for decades. This case highlights diagnostic and treatment challenges, especially in patients with disabilities like Down syndrome.

More Related Videos

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

435
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

2.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
07:11

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants

Published on: May 23, 2020

8.1K
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

435
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

2.1K

Area of Science:

  • Dentistry
  • Orthodontics
  • Genetics

Background:

  • Idiopathic condylar resorption (ICR) is a rare, challenging condition affecting the temporomandibular joint.
  • Diagnosis and treatment of ICR are often complex, requiring specialized approaches.

Observation:

  • A case report details a patient with Down syndrome experiencing asymptomatic bilateral condylar resorption during adolescence.
  • Symptomatic presentation of pain on chewing occurred 20 years after the initial asymptomatic phase.
  • Treatment, including orthodontic and surgical planning, was ultimately discontinued due to patient non-compliance.

Findings:

  • This case represents the first reported instance of ICR in a patient with Down syndrome presenting with such a delayed symptomatic onset.
  • Untreated ICR can remain asymptomatic for extended periods before manifesting clinically.

Implications:

  • Emphasizes the need for heightened vigilance and tailored management strategies for patients with disabilities, particularly those with Down syndrome, concerning ICR.
  • Highlights the long-term consequences of untreated ICR and the critical role of patient compliance in treatment success.