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Crystallographic snapshot of an arrested intermediate in the biomimetic activation of CO2
Sarah L Ackermann1, David J Wolstenholme, Chris Frazee
1Department of Chemistry, University of New Brunswick, P.O. Box 4400, Fredericton, N.B., E3B 5A3 (Canada).
Abstract:
The design of molecular catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biological systems. Herein, we report how the bulky arms of the cations in [(n C4 H9 )4 N](+) [HCO3 ](-) give rise to a host scaffold that emulates the substrate binding sites in carbonic anhydrase enzymes, affording a unique glimpse of an arrested intermediate in the base-mediated binding and activation of CO2 .
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