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Related Experiment Video

Updated: Apr 21, 2026

An Orthotopic Model of Murine Bladder Cancer

An Orthotopic Model of Murine Bladder Cancer

Published on: February 6, 2011

True aqueductal tumors: a unique entity.

Jonathan Roth¹, Kaisorn L Chaichana, George Jallo

¹Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv University, 6 Weizman Street, Tel Aviv, 64239, Israel, jonaroth@gmail.com.

Acta Neurochirurgica

|November 8, 2014

Summary

Pure aqueductal tumors (ATs) are rare and often cause obstructive hydrocephalus. Treatment prioritizes cerebrospinal fluid drainage, with resection reserved for growing tumors.

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Area of Science:

Neuro-oncology
Neurosurgery
Neuropathology

Background:

Pure aqueductal tumors (ATs) are distinct from pineal or tectal tumors, being centered within the cerebral aqueduct.
These rare tumors are often misclassified with adjacent lesions, necessitating focused study.
This multicenter study details the clinical experience with pure ATs.

Purpose of the Study:

To characterize the clinical presentation, treatment strategies, and outcomes for patients with pure aqueductal tumors.
To evaluate the efficacy of different management approaches for ATs, including conservative and surgical interventions.

Main Methods:

Retrospective data collection from three tertiary centers (1999-2013).
Analysis included presenting symptoms, treatment paradigms, surgical approaches, pathology, and patient outcomes.
Patient demographics and tumor characteristics were reviewed.

Main Results:

Sixteen patients with ATs were treated, aged 5.5 to 57 years.
Hydrocephalus was the primary presentation in 13 patients; two were incidental findings.
Endoscopic third ventriculostomy (ETV) was performed in 13 patients, with two undergoing simultaneous biopsy. Three patients underwent resection for tumor progression. Pathologies included glioblastoma, glioneural tumor, and ependymoma. Non-resected tumors showed stability or minimal growth.

Conclusions:

Aqueductal tumors (ATs) are rare and typically present with obstructive hydrocephalus.
Cerebrospinal fluid (CSF) diversion, preferably ETV, is the primary treatment. Endoscopic biopsy is an option in select cases.
Tumor resection is reserved for progressive lesions, with trans-fourth ventricular or trans-choroidal approaches suggested for safety.