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Sequential genital infections with herpes simplex virus types 1 and 2
A M al Samarai1, A A Shareef, G R Kinghorn
1Department of Microbiology, Basrah Medical College, Iraq.
Genitourinary Medicine
|January 1, 1989
Summary
Genital herpes can be caused by both herpes simplex virus (HSV) type 1 and type 2. Isolating different HSV types during separate clinical episodes is crucial for evaluating antiviral drug resistance in treatment studies.
Area of Science:
- Virology
- Immunology
Background:
- Genital herpes is a common sexually transmitted infection.
- Herpes simplex virus (HSV) is the causative agent, with two main types: HSV-1 and HSV-2.
Observation:
- HSV types 1 and 2 were identified using an enzyme-linked immunosorbent assay (ELISA).
- Different HSV types were isolated from the same individuals across distinct clinical episodes of genital herpes.
Findings:
- The study successfully typed HSV-1 and HSV-2 from patients with genital herpes.
- Co-infection or sequential infection with different HSV types within the same patient was observed.
Implications:
- Accurate typing of HSV is essential for understanding disease progression.
- This finding impacts the assessment of antiviral drug resistance in clinical trials for genital herpes.
- Further research may be needed to explore the clinical significance of sequential HSV type infections.