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Oral glucose solution to alleviate pain induced by intramuscular injections in preterm infants

Derya Uzelli1, Ülkü Yapucu Güneş

  • 1Katip Çelebi University, School of Nursing, İzmir, Turkey.

Journal for Specialists in Pediatric Nursing : JSPN
|November 8, 2014
PubMed

Insights

Administering a 5% oral glucose solution before intramuscular injections significantly reduced pain and crying in preterm infants. This simple intervention improved physiological markers, indicating a pain-relieving effect.

Area of Science:

  • Neonatal care
  • Pain management in infants
  • Clinical pharmacology

Background:

  • Intramuscular injections are a common source of acute pain for preterm infants.
  • Effective and safe pain relief strategies are crucial for this vulnerable population.

Purpose of the Study:

  • To evaluate the efficacy of a 5% oral glucose solution in mitigating pain experienced by preterm infants during intramuscular injections.

Main Methods:

  • A prospective, randomized, controlled, unblinded trial was conducted.
  • Eighty preterm infants (N = 80) were enrolled in the study.
  • Pain and physiological responses were measured before, during, and after the procedure.

Main Results:

  • Infants receiving oral glucose demonstrated significantly lower pain scores (p < .001).
  • Reduced crying time (p < .001), improved oxygen saturation (p < .001), and a lower heart rate post-procedure were observed.
  • These findings indicate a clear analgesic effect of oral glucose.

Conclusions:

  • Oral glucose solution, even at a low dose, appears to provide a pain-relieving effect in preterm infants.
  • Pre-procedure administration of oral glucose is a promising strategy for pain management in this population.
Abstract

Keywords:
Glucoseintramuscular injectionpain intensitypreterm infant

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