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Updated: Apr 21, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

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Published on: January 11, 2020

Late-stage [¹⁸F]Fluorination: New Solutions to Old Problems.

Allen F Brooks¹, Joseph J Topczewski², Naoko Ichiishi²

¹Department of Radiology, The University of Michigan Medical School Ann Arbor MI, USA.

Chemical Science

|November 8, 2014

Summary

New collaborations between chemists and PET Centers have advanced late-stage radiolabeling strategies. These developments enable the introduction of fluorine-18 into complex molecules for research and diagnostics.

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Area of Science:

Radiochemistry and Medicinal Chemistry
Nuclear Medicine and Molecular Imaging

Background:

Recent years have fostered collaborations between organometallic chemists, fluorine chemists, and PET Centers.
These partnerships are crucial for advancing radiolabeling techniques.

Purpose of the Study:

To highlight recent advancements in late-stage fluorination using fluorine-18.
To review key milestones in the development of novel radiolabeling strategies since 2011.

Main Methods:

Review of recent literature and collaborative research.
Analysis of new synthetic strategies for incorporating fluorine-18.

Main Results:

Development of multiple new strategies for late-stage introduction of fluorine-18.
Successful application of these methods in complex bioactive molecules.

Conclusions:

Collaborative efforts have significantly improved the ability to synthesize fluorine-18 labeled compounds.
These advancements are vital for molecular imaging and drug development.