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A case of priapism with risperidone.

Almari Ginory¹, Mathew Nguyen¹

¹Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA.

Case Reports in Psychiatry

|November 8, 2014

Summary

Priapism, a prolonged erection, can be a side effect of antipsychotic medications like risperidone. Patients with a history of priapism should be monitored closely when prescribed new psychotropic drugs.

Area of Science:

Urology
Pharmacology
Psychiatry

Background:

Priapism is a urologic emergency characterized by prolonged penile erection.
Psychotropic medications, particularly antipsychotics, are known causes of priapism.
Alpha-1 antagonism is a proposed mechanism for antipsychotic-induced priapism.

Purpose of the Study:

To report a case of new-onset priapism associated with risperidone in a patient with a history of schizophrenia and trazodone-induced priapism.
To highlight the importance of considering prior medication-induced priapism when prescribing psychotropic agents.

Main Methods:

Case report of a 50-year-old male with schizophrenia.
Clinical presentation of new-onset priapism.
Treatment involved discontinuation of risperidone, corpus cavernosum drainage, and intracavernosal phenylephrine injections.

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Main Results:

The patient experienced priapism while on risperidone.
Successful treatment was achieved with conservative measures and medication cessation.

Conclusions:

Risperidone can induce priapism, potentially through alpha-1 antagonism.
Patients with a history of medication-induced priapism have an increased risk.
Patient education and careful medication history are crucial in managing psychotropic drug prescriptions.