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Depression associated with enalapril.
1Department of Psychiatry, University of Missouri, Columbia, Mo.
Southern Medical Journal
|March 1, 1989
Summary
Enalapril use led to a major depressive episode in this patient. Previous antidepressant responses to propranolol and atenolol suggest a susceptibility to central nervous system effects from medications.
Area of Science:
- Pharmacology
- Neuroscience
- Psychiatry
Background:
- Patient history includes previous depressive episodes.
- Previous episodes were associated with beta-blocker medications (propranolol, atenolol).
Observation:
- The current major depressive episode emerged during enalapril therapy.
- Enalapril is an angiotensin-converting enzyme (ACE) inhibitor with known CNS effects.
Findings:
- Enalapril is implicated as the causative agent for the current major depressive episode.
- The patient's history suggests a potential predisposition to medication-induced depression.
Implications:
- Clinicians should consider ACE inhibitors like enalapril in the differential diagnosis of new-onset depression.
- This case highlights the importance of a thorough medication review in patients presenting with depressive symptoms.