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Updated: Jul 31, 2026

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Published on: January 25, 2016
Non-rapid-eye-movement parasomnia with behavior disorder.
1Psychiatry Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Mo 65201.
This case study highlights a successful treatment for NREM parasomnia involving violent aggression. Imipramine therapy proved effective when clonazepam failed, offering new hope for managing aggressive parasomnias.
Area of Science:
- Neurology
- Sleep Medicine
- Psychiatry
Background:
- Non-rapid eye movement (NREM) parasomnias are disruptive sleep disorders.
- Violent aggression during sleep presents a significant clinical challenge.
- Treatment options for severe NREM parasomnias can be limited.
Observation:
- A patient presented with recurrent episodes of violent aggression directed at another person during NREM sleep.
- Previous treatment attempts with clonazepam were unsuccessful in mitigating the aggressive behaviors.
Findings:
- Imipramine, a tricyclic antidepressant, was administered to the patient.
- Successful resolution of violent aggressive episodes was observed following imipramine therapy.
Implications:
- This case suggests imipramine may be a viable therapeutic option for NREM parasomnias with violent aggression.
- Further research is warranted to explore the efficacy of imipramine in larger cohorts.
- Understanding the neurobiological underpinnings of aggression in parasomnias is crucial for developing targeted treatments.
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