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Related Experiment Videos

Depression associated with enalapril.

J F Patterson1

  • 1Department of Psychiatry, University of Missouri, Columbia, Mo.

Southern Medical Journal
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Enalapril use led to a major depressive episode in this patient. Previous antidepressant responses to propranolol and atenolol suggest a susceptibility to central nervous system effects from medications.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Psychiatry

Background:

  • Patient history includes previous depressive episodes.
  • Previous episodes were associated with beta-blocker medications (propranolol, atenolol).

Observation:

  • The current major depressive episode emerged during enalapril therapy.
  • Enalapril is an angiotensin-converting enzyme (ACE) inhibitor with known CNS effects.

Findings:

  • Enalapril is implicated as the causative agent for the current major depressive episode.
  • The patient's history suggests a potential predisposition to medication-induced depression.

Implications:

  • Clinicians should consider ACE inhibitors like enalapril in the differential diagnosis of new-onset depression.

Related Experiment Videos

  • This case highlights the importance of a thorough medication review in patients presenting with depressive symptoms.