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Warthin's tumor with malignant lymphoma. DNA analysis of paraffin-embedded tissue
1Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania.
American Journal of Clinical Pathology
|March 1, 1989
Abstract:
The authors report a case of malignant lymphoma, small lymphocytic type, involving the lymphoid stroma of a Warthin's tumor of the parotid gland. This was confirmed by the presence of a monoclonal immunoglobulin heavy chain gene rearrangement, demonstrated by Southern blot hybridization of DNA extracted from paraffin-embedded tissue. Similar techniques showed only germline immunoglobulin gene bands in two control cases of Warthin's tumor.