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Published on: February 17, 2023
"AND" logic gate regulated pH and reduction dual-responsive prodrug nanoparticles for efficient intracellular
Lan Bai1, Xiao-hui Wang, Fei Song
1Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China. songfei520@gmail.com yzwang@scu.edu.cn.
Abstract:
A dual-responsive drug delivery system simulating an AND logic gate is developed by core-cross-linking of a disulfide-containing anticancer prodrug with Cu(2+) for safe and efficient delivery of anticancer drugs. These prodrug nanoparticles are stable and exhibit nearly no premature drug release, and allow a fast drug release under simulated intracellular conditions, realizing a precise drug delivery towards cell nuclei.
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