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Updated: Apr 21, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Staphylococcus aureus infection of the optic nerve
Senad Osmanovic1, Omar M Al-Heeti, Amy Y Lin
1Departments of Ophthalmology and Visual Sciences (SO, AYL, VKA, HEM), Medicine (OA-H), Pathology (AYL), and Radiology (SZ), University of Illinois College of Medicine, Chicago, Illinois; Department of Clinical Pharmacy and Outcomes Sciences (JAJ), South Carolina College of Pharmacy, Charleston, South Carolina; and Division of Infectious Disease (SM, MCP), University of Illinois College of Medicine, Chicago, Illinois.
Abstract:
A 71-year-old woman presented with painful vision loss in the right eye followed by ophthalmoplegia. Magnetic resonance imaging demonstrated optic nerve sheath enlargement and enhancement. Biopsy of the optic nerve sheath revealed purulent and necrotic material that was positive for methicillin-sensitive Staphylococcus aureus. The patient underwent enucleation of the right eye and was treated with systemic antibiotics with clinical stabilization. Imaging, pathological and treatment aspects of optic nerve sheath abscess are discussed.
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