Related Experiment Video
Updated: Apr 21, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
The discovery of aurora kinase inhibitor by multi-docking-based virtual screening
Jun-Tae Kim1, Seo Hee Jung2, Sun Young Kang3
1Graduate School of New Drug Discovery and Development, Chungnam National University, Daehakno 99, Yuseong-gu, Daejeon 305-764, Korea. wowjtkim@gmail.com.
Abstract:
We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.

