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Updated: Apr 21, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

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Published on: December 16, 2022

Choroid plexus in the eye: a case study.

Bozho Todorich¹, Thomas J Cummings, Sharon Freedman

¹*Duke Eye Center, Duke University Medical Center, Durham, North Carolina; and †Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Retinal Cases & Brief Reports

|November 11, 2014

Summary

This summary is machine-generated.

This case report details a rare instance of choroid plexus tissue found in a human eye, associated with total retinal detachment (RD) and glaucoma in an infant. This discovery suggests a potential role for choroid plexus in the development of retinal detachment.

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Area of Science:

Ophthalmology
Pediatric Pathology
Developmental Biology

Background:

Posterior coloboma is a congenital condition affecting eye development.
Retinal detachment (RD) and secondary glaucoma are serious ocular conditions.
The presence of metaplastic tissue in congenital ocular anomalies is rare.

Observation:

A 3-month-old infant presented with leukocoria and an enlarged eye.
The patient was diagnosed with total retinal detachment (RD), secondary glaucoma, and posterior coloboma.
Orbital imaging excluded retinoblastoma.

Findings:

Histologic analysis revealed metaplastic retinal pigment epithelium with an abrupt transition to choroid plexus tissue within the posterior coloboma.
The eye exhibited neovascularization of the iris and total RD.
Elevated intraocular pressures persisted despite maximal medical and surgical interventions, leading to enucleation.

Implications:

This is the first reported case of choroid plexus within the human eye.
The findings suggest that choroid plexus tissue associated with coloboma may contribute to the pathogenesis of RD, potentially by secreting cerebrospinal fluid into the subretinal space.
This case expands our understanding of rare congenital ocular malformations and their potential mechanisms.