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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
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Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Updated: Apr 21, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

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[Malignant hyperthermia].

T Metterlein1, F Schuster, B M Graf

  • 1Klinik für Anästhesiologie, Universitätsklinikum Regensburg, Franz-Josef-Strauss Allee 11, 93051, Regensburg, Deutschland, thomas.metterlein@ukr.de.

Der Anaesthesist
|November 12, 2014
PubMed
Summary
This summary is machine-generated.

Malignant hyperthermia (MH) is a rare genetic myopathy triggered by anesthetics. Early diagnosis and dantrolene treatment significantly reduce mortality from this potentially fatal condition.

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Area of Science:

  • Pharmacology
  • Genetics
  • Physiology

Context:

  • Malignant hyperthermia (MH) is a rare, inherited myopathy often presenting asymptomatically.
  • Exposure to specific anesthetic agents or succinylcholine can trigger life-threatening hypermetabolic crises in susceptible individuals.

Purpose:

  • To elucidate the pathophysiology of malignant hyperthermia.
  • To highlight the clinical manifestations and diagnostic approaches for MH.
  • To emphasize the importance of timely treatment with dantrolene.

Summary:

  • MH involves a genetic defect in the ryanodine receptor complex, leading to uncontrolled calcium release from the sarcoplasmic reticulum.
  • This calcium dysregulation causes muscle contraction, increased cellular metabolism, energy depletion, muscle cell damage, and cardiovascular collapse.
  • Early symptoms include hypoxia and arrhythmias, with fever often appearing later. Dantrolene is a crucial therapeutic agent.

Impact:

  • The development of dantrolene has dramatically reduced MH-related mortality to below 10%.
  • In vitro contracture testing (IVCT) and genetic mutation analysis are key diagnostic tools for identifying MH predisposition.
  • Ongoing research aims to develop less invasive diagnostic methods.