[Ocular manifestations of immune reconstitution inflammatory syndrome]

To investigate the ocular manifestations of immune reconstitution inflammatory syndrome.

Retrospective study. 372 patients were diagnosed as acquired immune deficiency syndrome from April 1997 to December 2012. The examination included best-corrected visual acuity, slit-lamp biomicroscopy, mydriatic fundus examination and colored fundus photography. Systemic examination including CD4(+)T- lymphocyte count and HIV viral load test before and after HAART treatment.

Fifty three eyes (33 patients) were diagnosed as cytomegalovirus retinitis, among which 16 eyes (10 patients) were later presented with immune reconstitution inflammatory syndrome after highly active anti-retroviral therapy. There are 9 males and 1 female, aged from 24 to 57 years old, with a mean of (39.0 ± 10.6) years old. The duration of HAART was 2 weeks to 2 years, with a mean of 5.3 months. All of the 16 eyes had decreased visual acuity, and 2 eyes had floaters. The best corrected visual acuity (BCVA) was light perception in 2 eyes, hand move to 0.05 in 5 eyes, 0.1 to 0.5 in 6 eyes, 0.6 to 1.0 in 3 eyes. 8 eyes appeared active iridocyclitis and 5 eyes appeared inactive iridocyclitis, 5 eyes had lens opacity, 9 eyes had vitreitis, 1 eye had pale optic disc, 2 eyes had optic disc edema, 4 eyes were found retinal detachment.

The improvement of the understanding of the ocular manifestations of IRIS is essential for diagnosis and treatment.