Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth
Joon Young Kim1, Michael I Goran2,3, Claudia M Toledo-Corral2
1Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA.
Objective:
One hour (1-hr) glucose during an oral glucose tolerance test (OGTT) is an emerging biomarker for type 2 diabetes. We compared the predictive power of 1-hr glucose to traditional glycemic markers for prospectively identifying prediabetes in youth.
Research Design And Methods:
Obese normoglycemic Latino youth (N = 116) were assessed at baseline for glycated hemoglobin (HbA1c), fasting, 1-hr, and 2-hr glucose during an OGTT and were followed for up to 8 yr for the development of prediabetes. Receiver operating characteristic (ROC) curves were used and a multivariable prediction model was developed.
Results:
The area under the 1-hr glucose ROC curve was the most powerful predictor of prediabetes over time [0.73, 95% confidence interval (CI) = 0.64-0.83]. However, combining all indicators into a single model was superior to individual marker models (0.77, 95% CI = 0.690.86).
Conclusions:
These results further support the utility of 1-hr glucose during an OGTT as a prospective marker of diabetes risk in youth.
More Related Videos
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Diabetes: Symptoms, Diagnosis, and Complications
Type II Diabetes I: Introduction
Type II Diabetes II: Pathophysiology
Type I Diabetes III: Clinical Manifestations
