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Tegafur-induced acral hyperpigmentation.

Vera Teixeira1, Ricardo Vieira1, Américo Figueiredo1

  • 1Department of Dermatology, Coimbra University Hospital, Portugal.

Dermatology Reports
|November 12, 2014
PubMed
Summary
This summary is machine-generated.

Tegafur, a 5-fluorouracil (5-FU) prodrug for gastrointestinal cancers, can cause skin side effects. This case highlights acral hyperpigmentation as a notable cutaneous adverse event during tegafur treatment.

Keywords:
5-fluorouracilacral hyperpigmentation.tegafur

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Tegafur is an oral prodrug of 5-fluorouracil (5-FU) used for advanced gastrointestinal neoplasms.
  • It offers oral administration and reduced hematologic toxicity compared to 5-FU.
  • Gastrointestinal toxicity is the primary dose-limiting factor for tegafur.

Observation:

  • Cutaneous adverse effects associated with tegafur are diverse.
  • These include mucositis, photosensitivity, hyperpigmentation (diffuse or nail-restricted), palmoplantar erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly, and Raynaud phenomenon.
  • A specific case of acral hyperpigmentation during tegafur treatment is presented.

Findings:

  • Acral hyperpigmentation is a potential cutaneous adverse effect of tegafur therapy.
  • This finding contributes to the understanding of tegafur's dermatological toxicity profile.
  • The case illustrates a specific manifestation of skin toxicity.

Implications:

  • Awareness of acral hyperpigmentation is crucial for clinicians managing patients on tegafur.
  • Early recognition and management of this side effect may improve patient adherence and quality of life.
  • Further research into the mechanisms and prevalence of tegafur-induced dermatological toxicities is warranted.