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A triple-function zwitterion for preparing water compatible diclofenac imprinted polymers.
Feng Shen1, Qingxi Zhang, Xueqin Ren
1Department of Plant Nutrition, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, P. R. China.
Chemical Communications (Cambridge, England)
|November 13, 2014
Summary
Researchers developed a novel zwitterionic material for creating water-compatible diclofenac imprinted polymers. This innovative polymer demonstrates excellent template imprinting and resistance to protein adsorption in water.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Analytical Chemistry
Background:
- Developing selective polymers for drug imprinting in aqueous environments is challenging due to protein adsorption.
- Traditional imprinted polymers often suffer from poor performance in biological media.
Purpose of the Study:
- To synthesize a novel zwitterionic monomer that functions as both a functional monomer and crosslinker.
- To create water-compatible diclofenac imprinted polymers with enhanced protein resistance.
- To evaluate the imprinting efficiency and anti-protein adsorption capabilities of the novel polymer.
Main Methods:
- Synthesis of a novel zwitterionic compound.
- Preparation of diclofenac imprinted polymers using the synthesized zwitterion.
- Evaluation of imprinting efficiency using template binding assays.
- Assessment of protein adsorption resistance in aqueous medium.
Main Results:
- A novel zwitterion was successfully synthesized, acting as both a functional monomer and crosslinker.
- Water-compatible diclofenac imprinted polymers were prepared.
- The imprinted polymer exhibited high imprinting efficiency for diclofenac.
- The polymer demonstrated strong resistance to protein adsorption in aqueous solutions.
Conclusions:
- The novel zwitterionic monomer is effective for creating water-compatible imprinted polymers.
- This material offers a promising solution for molecular imprinting in biological or aqueous settings.
- The developed polymer shows potential for applications requiring selective recognition and anti-fouling properties.
