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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: Apr 21, 2026

Murine Model of Allergen Induced Asthma
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Published on: May 14, 2012

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Mouse models of allergic asthma.

Matthew Gold1, David Marsolais, Marie-Renee Blanchet

  • 1The Biomedical Research Centre, Department of Experimental Medicine, The University of British Columbia, Vancouver, BC, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|November 13, 2014
PubMed
Summary

Choosing the right mouse model for allergic asthma research is crucial. This study compares three models—ovalbumin, modified ovalbumin, and house dust mite—to aid researchers in selecting the most effective approach for studying T-helper type 2 (Th2) inflammation.

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Animal Models

Background:

  • Murine models are essential for studying T-helper type 2 (Th2)-driven allergic asthma.
  • The classical ovalbumin model is widely used, but naturally occurring antigens are gaining importance.
  • A wide variety of models exist, complicating selection for new investigators.

Purpose of the Study:

  • To describe and compare three distinct mouse models of allergic asthma.
  • To aid researchers in selecting the most appropriate model for their specific hypothesis.
  • To highlight the differences and characteristics of various asthma models.

Main Methods:

  • Description of the classical ovalbumin-induced asthma model.
  • Introduction of a modified ovalbumin model, emphasizing mast-cell dependence.
  • Presentation of a house dust mite antigen-induced asthma model.

Main Results:

  • Detailed characterization of each of the three described mouse models.
  • Discussion of the differences between the ovalbumin and house dust mite models.
  • Identification of a mast-cell dependent modified ovalbumin model.

Conclusions:

  • The choice of an appropriate mouse model is critical for understanding allergic asthma.
  • Comparing different models aids in selecting the best fit for specific research questions.
  • This review facilitates the selection of suitable models for intricate Th2 inflammatory diseases.