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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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[Left ventricular radial and longitudinal systolic function derived from magnetic resonance imaging in hypertrophic

Lisha Mu1, Wenling Li, Li Zhu2

  • 1Department of Imaging and Nuclear Medicine,Ningxia Medical University, Yinchuan 750004, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|November 13, 2014
PubMed

Insights

In hypertrophic cardiomyopathy (HCM), left ventricular (LV) longitudinal systolic function is reduced, while radial function remains unchanged. Longitudinal shortening (LS) changes better reflect systolic function in HCM patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • Assessing left ventricular (LV) systolic function is crucial for managing HCM.
  • Advanced cardiac MRI techniques offer detailed myocardial assessment.

Purpose of the Study:

  • To evaluate LV radial and longitudinal systolic function in HCM patients using 3.0 T MRI.
  • To compare systolic function parameters between HCM patients and healthy individuals.
  • To determine which parameter best reflects myocardial function in HCM.

Main Methods:

  • Cardiac MRI with a fast imaging employing steady-state (FIESTA) sequence was performed.
  • Sixteen HCM patients and twenty healthy adults were included.
  • LV ejection fraction (LVEF), longitudinal shortening (LS), and fractional shortening (FS) were measured.

Main Results:

  • HCM patients showed asymmetric hypertrophy.
  • LV ejection fraction (LVEF) and fractional shortening (FS) were significantly higher in HCM patients, while longitudinal shortening (LS) was significantly lower.
  • LS was negatively correlated with the number of hypertrophied segments in HCM patients.

Conclusions:

  • LV longitudinal systolic function is reduced in HCM patients.
  • LV radial systolic function is preserved in HCM patients.
  • Longitudinal shortening (LS) changes are a more sensitive indicator of systolic dysfunction in HCM.
Abstract

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