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Receptors and receptor binding methods in drug discovery
1Department of Neuroscience and Cancer, Pfizer Pharmaceuticals, Connecticut 06340.
Progress in Clinical and Biological Research
|January 1, 1989
Summary
Receptor binding assays offer a fast, affordable, and reliable method for studying drug-receptor interactions. These assays are crucial for understanding disease-related receptor dysfunctions and identifying drug actions.
Area of Science:
- Pharmacology
- Biochemistry
- Drug Discovery
Background:
- Receptor binding assays are the most direct method for measuring drug-receptor interactions.
- These assays offer inexpensive, rapid, and reliable information on chemical agent-receptor interactions.
- Understanding receptor function is key to understanding various diseases.
Purpose of the Study:
- To highlight the importance of receptor binding assays in drug discovery.
- To emphasize their role in identifying the mechanism of action for drugs, particularly psychotherapeutic agents.
- To advocate for their inclusion in the drug discovery process.
Main Methods:
- Utilizing receptor binding assays to study drug-receptor interactions.
- Analyzing the data generated from these binding studies.
- Comparing binding assay results with in vivo testing.
Main Results:
- Receptor binding assays provide direct, cost-effective, and rapid insights into drug-receptor interactions.
- These methods are valuable for diagnosing receptor dysfunctions linked to diseases.
- Binding studies are essential for pinpointing the sites of action for psychotherapeutic drugs.
Conclusions:
- Receptor binding assays are a powerful tool in drug discovery and should not be overlooked.
- They offer critical information for understanding drug mechanisms and disease pathology.
- While not replacing in vivo testing, binding assays are a vital component of the drug discovery armamentarium.