Polypoidal choroidal vasculopathy associated with tilted disk syndrome
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Updated: Apr 21, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Enrico Peiretti1, Reza Iranmanesh, Lawrence A Yannuzzi
1From the *Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy; and †The Vitreous-Retina-Macula Consultants of New York, the LuEsther T. Mertz Retinal Research Center, and Manhattan Eye, Ear, and Throat Hospital, New York, New York.
Purpose:
To describe a complication of tilted disk syndrome-macular serous retinal detachment caused by development of polypoidal choroidal vasculopathy.
Methods:
A 65-year-old patient with visual loss and metamorphopsia was evaluated with fluorescein and indocyanine green angiography (ICG) and optical coherence tomography. Subsequently, photodynamic therapy (PDT) with verteporfin was administered.
Results:
Fundus examination showed classic features of tilted disk syndrome as well as a unilateral macular serous detachment secondary to a polypoidal lesion, which was clearly outlined by ICG angiography at the site of a macular lacquer crack. The lesion resolved after PDT. Two years after treatment, no recurrence was observed, and visual acuity was 20/25 without distortion.
Conclusions:
In this patient with tilted disk syndrome, unilateral polypoidal choroidal vasculopathy was diagnosed by ICG angiography and treated successfully with PDT.
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