OPTIC DISK PIT: A TRIGGER FOR SECONDARY MULTIPLE EVANESCENT WHITE DOT SYNDROME
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Updated: May 8, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Shivesh Varma1,2, Royce W S Chen3, Jeffrey M Liebmann3
1Vitreous Retina Macula Consultants of New York, New York.
Purpose:
We describe a case of secondary multiple evanescent white dot syndrome (MEWDS) with optic disk pit as the underlying triggering pathology.
Methods:
Observational case report.
Results:
A 41-year-old man with a background of right optic disk pit presented with right eye loss of vision and photopsia. Visual acuity at presentation was 20/100. He was found to have clinical and multimodal imaging features consistent with right unilateral MEWDS, and the spatial distribution of lesions made it likely that the optic disk pit was the trigger. Fundus autofluorescence revealed hyperautofluorescent "spots" that gradually faded over serial imaging, with the complete absence of hyperautofluorescent "dots." For 3 months of follow-up, visual acuity recovered to 20/25.
Conclusion:
Optic disk pit may act as a trigger for secondary MEWDS, which is an increasingly recognized epiphenomenon. Secondary MEWDS may present as "spots without dots," and we hypothesize that this feature may differentiate it from primary MEWDS.
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