Related Experiment Video
Updated: Apr 21, 2026
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
Published on: December 7, 2016
Orbital hemorrhage after intravitreal injection
Gary Shienbaum1, Richard S Kaiser, Scott M Goldstein
1*Retina Service †Oculoplastics and Orbital Surgery Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Purpose:
To describe a case of orbital hemorrhage after the administration of intravitreal ranibizumab.
Methods:
Retrospective chart review of one case.
Results:
A 73-year-old woman with a history of atrial fibrillation on coumadin anticoagulation (international normalized ratio = 3.4) presented with decreased vision and metamorphopsia in her right eye for 2 weeks duration. Examination was consistent with a diagnosis of neovascular age-related macular degeneration in the right eye. After one injection of intravitreal ranibizumab, she developed a bullous subconjunctival hemorrhage that extended into an orbital hemorrhage.
Conclusion:
Intravitreal injection may result in orbital hemorrhage, particularly in the anticoagulated patient.
