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Recurrence of acute lymphocytic leukemia diagnosed by subretinal biopsy
Alok S Bansal1, G Baker Hubbard, Daniel F Martin
1From the Department of Ophthalmology, Emory University, Atlanta, Georgia.
Purpose:
To report a case of leukemia relapse in the subretinal space that was diagnosed by transvitreal subretinal biopsy.
Methods:
Case report and literature review.
Results:
A 5-year-old girl with prior history of acute lymphocytic leukemia who was in clinical remission was examined for a unilateral subretinal mass. Her systemic evaluation was negative for recurrence of the acute lymphocytic leukemia. Pars plana vitrectomy with a subretinal biopsy showed leukemic cells confirmed by flow cytometric immunophenotyping. The patient subsequently underwent bone marrow transplantation with regression of the subretinal mass.
Conclusion:
Leukemia relapse may occur in the subretinal space. A relapse may be successfully diagnosed with a subretinal biopsy through a pars plana vitrectomy.
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