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Updated: Apr 21, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Bilateral diffuse uveal melanocytic proliferation and loss of retinal pigment epithelium
Shantan Reddy1, Jay Klancnik, Marcus S Edelstein
1From the *Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital and New York University School of Medicine, New York, New York; †Vitreous-Retina-Macula Consultants of New York, New York, New York; ‡State University of New York Downstate Medical Center, Brooklyn, New York; and §Wills Eye Hospital, Philadelphia, Pennsylvania.
Purpose:
To describe a fundus autofluorescent photographic pattern in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with occult esophageal carcinoma.
Methods:
Observational case report.
Results:
Color photography captured multiple round areas of discoloration throughout the fundus in a background of orange pigmentation that may have represented a lipofuscin-laden retinal pigment epithelium (RPE). Autofluorescence photography showed extensive nummular areas of hypoautofluorescence interspersed between areas of hyperautofluorescence as a result of extensive deposition of lipofuscin within the RPE.
Conclusion:
Our case attests to the utility of autofluorescence photography as a sensitive, noninvasive imaging modality for the early detection of BDUMP.
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