Related Experiment Video
Updated: Apr 21, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Retinoblastoma in oculocutaneous albinism
Fariba Ghassemi1, Carol L Shields, Cesare Pirondini
1From the *Ocular Oncology Service and †Pathology Department, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Purpose:
To report a case of retinoblastoma in a child with oculocutaneous albinism (OCA).
Methods:
A 24-month-old girl with classic features of OCA developed leukocoria in the left eye.
Results:
The patient was found to have an endophytic retinoblastoma and an exophytic retinoblastoma, with a total retinal detachment and neovascularization of the iris. Enucle-ation was performed, and histopathology confirmed massive retinoblastoma with optic nerve involvement to the posterior margin of the lamina cribrosa but no choroidal invasion.
Conclusion:
Although rare, retinoblastoma can occur in children with OCA.
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