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Updated: Apr 21, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Senior-loken syndrome complicated with severe coats disease-like exudative retinopathy
Takaki Sato1, Masashi Mimura, Tetsuya Sugiyama
1From the Department of Ophthalmology, Osaka Medical College, Osaka, Japan.
Background:
Senior-Loken syndrome is a rare disorder that combines juvenile nephronophthisis with retinitis pigmentosa.
Methods:
Case report.
Results:
A 9-year-old Japanese girl diagnosed with Senior-Loken syndrome subsequently developed severe Coats disease-like exudative retinopathy. Although retinal coagulation, pars plana lensectomy, and vitrectomy were performed, she lost light perception in both eyes.
Conclusion:
Faulty vascular morphogenesis and its dysfunction might contribute to the development of Coats disease-like exudative retinopathy in Senior-Loken syndrome.
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