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Multicentric castleman disease with ocular involvement: a clinicopathologic case report
Geoffrey G Emerson1, Lyndell Lim, Marc Loriaux
1From the *Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; the †Department of Pathology and Medicine, Oregon Health & Science University, Portland, Oregon; and ‡Health Associates of Peace Harbor, Florence, Oregon.
Purpose:
To describe an ocular manifestation of Castleman disease, a rare lymphoproliferative disorder characterized by sheets of abundant plasma cells in the interfollicular spaces of lymph nodes, most commonly in the abdomen, mediastinum, and cervical chain.
Methods:
Clinicopathologic case report.
Patient:
A 69-year-old man with lymphadenopathy and bilateral choroidal infiltrates.
Results:
Initially, we suspected systemic lymphoma with ocular involvement. Lymph node biopsy revealed Castleman disease without a monoclonal component. Choroidal biopsy showed lymphocytic and plasma cell infiltration.
Conclusion:
To our knowledge, this is the first clinicopathologic report of multicentric Castleman disease involving the eye.
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