Multicentric castleman disease with ocular involvement: a clinicopathologic case report

Area of Science:

• Ophthalmology
• Hematology
• Pathology

Background:

• Castleman disease is a rare lymphoproliferative disorder.
• It typically involves lymph nodes in the abdomen, mediastinum, and cervical chain.
• Ocular involvement is uncommon.

Purpose of the Study:

• To describe a unique ocular manifestation of Castleman disease.
• To report the first clinicopathologic findings of multicentric Castleman disease involving the eye.

Main Methods:

• Clinicopathologic case report.
• Patient presented with lymphadenopathy and bilateral choroidal infiltrates.
• Diagnostic procedures included lymph node and choroidal biopsies.

Main Results:

• Lymph node biopsy confirmed Castleman disease without a monoclonal component.
• Choroidal biopsy revealed infiltration by lymphocytes and plasma cells.
• Initial suspicion of systemic lymphoma with ocular involvement was revised.

Conclusions:

• This is the first clinicopathologic report of multicentric Castleman disease presenting with ocular findings.
• Highlights the importance of considering Castleman disease in cases of unexplained choroidal infiltrates.