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Chorioretinitis and panuveitis in an infant with systemic langerhans cell histiocytosis
Hassan Rahman1, Steven Yeh, Thomas Arno Albini
1From the *Cullen Eye Institute, Baylor College of Medicine, Houston; and †Texas Children's Hospital, Houston, Texas.
Insights
Ocular inflammation, including panuveitis and chorioretinitis, can occur in infants with Langerhans cell histiocytosis. Early detection through fundus examination is recommended for better visual outcomes.
Area of Science:
- Ophthalmology
- Pediatrics
- Oncology
Background:
- Langerhans cell histiocytosis (LCH) is a rare disorder.
- Ocular manifestations of LCH, specifically panuveitis and chorioretinitis, are uncommon in infants.
- Limited fundus photographic evidence exists for these conditions in pediatric LCH cases.
Purpose of the Study:
- To document the fundus findings in an infant diagnosed with disseminated Langerhans cell histiocytosis.
- To highlight the presentation and management of ocular inflammation in pediatric LCH.
Main Methods:
- A case report detailing the clinical presentation of an infant with LCH.
- Fundus photography was utilized for documentation of ocular findings.
Main Results:
- The infant presented with panuveitis in the right eye and chorioretinitis in the left eye.
- Chemotherapy resulted in the resolution of chorioretinal lesions.
- Visual prognosis was guarded due to macular involvement and resulting amblyopia.
Conclusions:
- Infants diagnosed with Langerhans cell histiocytosis should undergo thorough ocular examination.
- Screening for chorioretinal involvement is crucial for early diagnosis and management.
- Prompt treatment can lead to lesion resolution, but visual impairment may persist.
Background:
Panuveitis and chorioretinitis in infants with Langerhans cell histiocytosis are rare and fundus photographic documentation is lacking in the literature.
Methods:
Case report with fundus photography.
Results:
The authors report a case of an infant with disseminated Langerhans cell histiocytosis who presented with panuveitis in the right eye and chorioretinitis in left eye. Treatment with chemotherapy led to resolution of chorioretinal lesions; however, the visual prognosis remained guarded because of the macular involvement and amblyopia.
Conclusion:
The authors recommend examination of infants with Langerhans cell histiocytosis for chorioretinal involvement.
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