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Elevated fasting insulin level significantly increases the risk of microalbuminuria

Jae-Hong Ryoo1, Sung Keun Park, Ju Young Jung

  • 1Department of Preventive Medicine, School of Medicine, Kyung Hee University.

Circulation Journal : Official Journal of the Japanese Circulation Society
|November 14, 2014
PubMed
Abstract

Insights

Elevated fasting insulin levels are linked to an increased risk of developing microalbuminuria, a marker of kidney damage. This finding highlights fasting insulin as a potential predictor for future kidney health in the general population.

Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Microalbuminuria is a significant predictor of long-term prognosis in both general and diabetic populations.
  • Insulin resistance (IR) is known to induce microalbuminuria.
  • The role of elevated fasting insulin, an early sign of IR, as an independent risk factor for microalbuminuria remains unclear.

Purpose of the Study:

  • To investigate the association between fasting insulin levels and the development of microalbuminuria in a general population.
  • To clarify if elevated fasting insulin is a risk factor for microalbuminuria.

Main Methods:

  • A cohort of 1,192 non-diabetic Korean men without microalbuminuria was followed for 5 years (2005-2010).
  • Participants were stratified into three groups based on fasting insulin levels.
  • Cox proportional hazards models were employed to assess the risk of microalbuminuria development.

Main Results:

  • During 4,013.0 person-years of follow-up, 51 new cases of microalbuminuria were identified.
  • The incidence of microalbuminuria progressively increased with higher fasting insulin tertiles (1.8% vs. 4.5% vs. 6.5%, P<0.001).
  • Hazard ratios for microalbuminuria were significantly elevated in the higher fasting insulin groups (tertile 2: 2.44, tertile 3: 3.30, P for trend 0.013).

Conclusions:

  • Elevated fasting insulin levels are significantly associated with the future development of microalbuminuria.
  • Fasting insulin level may serve as an early clinical indicator for predicting microalbuminuria.
  • This study suggests a potential link between insulin resistance markers and kidney health outcomes.

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