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Updated: Apr 21, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Cardiohepatic syndrome

Gerhard Poelzl1, Johann Auer

  • 1Clinical Division of Cardiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria, gerhard.poelzl@uki.at.

Current Heart Failure Reports
|November 14, 2014
PubMed

Insights

Heart and liver conditions are interconnected, with each potentially worsening the other. This review defines cardiohepatic syndrome (CHS) using the cardiorenal syndrome (CRS) model to explain its development and impact.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Growing evidence links heart disease and liver dysfunction.
  • The interplay between cardiac and hepatic health is increasingly recognized.

Purpose of the Study:

  • To define and describe cardiohepatic syndrome (CHS).
  • To utilize the cardiorenal syndrome (CRS) framework for understanding CHS.
  • To elucidate the pathophysiology, subtypes, and clinical outcomes of CHS.

Main Methods:

  • Review of existing literature on cardiohepatic and cardiorenal interactions.
  • Application of the cardiorenal syndrome (CRS) concept to cardiohepatic syndrome (CHS).

Main Results:

  • Cardiohepatic syndrome (CHS) involves bidirectional influence between heart and liver conditions.
  • The cardiorenal syndrome (CRS) model provides a useful analogy for understanding CHS pathophysiology.
  • CHS has distinct subtypes with associated morbidity and mortality.

Conclusions:

  • Cardiohepatic syndrome (CHS) represents a significant clinical entity.
  • Understanding CHS through the lens of cardiorenal syndrome (CRS) aids in comprehending its complex nature.
  • Further research into CHS subtypes and outcomes is warranted.

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