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Stabilization of poliovirus against heat inactivation
B L Dorval1, M Chow, A M Klibanov
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge.
Biochemical and Biophysical Research Communications
|March 31, 1989
Abstract:
Fatty acids and related compounds, as well as many salts, stabilize poliovirus against heat inactivation. Addition of myristate to poliovirus prevents heat-induced conformational changes which are detected by trypsin degradation of the virion. Using equilibrium dialysis, we found that several molecules of myristate bind per virion. The relative stabilizing potencies of the salts can be explained by the Hofmeister effect.