Sudden cardiac death in end stage renal disease: unlocking the mystery

Sudden cardiac death (SCD) is a major cause of concern in end stage renal disease (ESRD), contributing to 70% of cardiovascular mortality and 27% of all-cause mortality in dialysis patients. Yet its mechanisms and pathogenesis remain largely obscure. This review discusses the potential reasons for an exaggerated risk of SCD in ESRD populations taking into account recent studies and registry data and additionally explores the reasons for the reported recent decline in SCD. The types of arrhythmias typical of the hemodialysis population are yet to be fully characterised and in this paper, we introduce an ongoing implantable loop recorder (ILR) based study in hemodialysis patients--CRASH ILR (Cardio Renal Arrhythmia Study in Haemodialysis patients using Implantable Loop Recorders). The findings of this study will hopefully guide the design and implementation of larger ILR based studies before undertaking larger scale interventional therapeutic trials in this high risk population.