Related Experiment Video
Updated: Apr 21, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Treatment of ocular surface squamous neoplasia with topical Aloe vera drops
Mausam R Damani1, Ankoor R Shah, Carol L Karp
1*Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA; and †Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, FL.
Purpose:
To report a case of ocular surface squamous neoplasia (OSSN) that resolved with topical Aloe vera eye drop treatment.
Methods:
A 64-year-old Hispanic woman with a lesion typical for OSSN in her left eye was followed up with multiple clinical examinations and ocular surface photographs to document changes over time with A. vera-based topical treatment.
Results:
The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years.
Conclusions:
Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Ophthalmic Drug Delivery Systems

