Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

1.8K
Anterior segment high-resolution optical coherence tomography (HR-OCT) is a promising non-invasive modality for the diagnosis and therapeutic evaluation of ocular surface squamous neoplasia (OSSN). Here, the system setup, scanning technique, and representative diagnostic results are...
1.8K
Induction of Ocular Surface Inflammation and Collection of Involved Tissues06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

2.8K
Ocular surface inflammation harms the ocular surface tissues and compromises vital functions of the eye. The present protocol describes a method to induce ocular inflammation and collect compromised tissues in a mouse model of Meibomian gland dysfunction (MGD).
2.8K
A Method to Induce Ocular Surface Inflammation in a Murine Model03:06

A Method to Induce Ocular Surface Inflammation in a Murine Model

648
This video demonstrates a method to induce ocular surface inflammation and meibomian gland dysfunction in a murine model. Stimulation of the mouse's immune system using an immunogen and later restimulation with the same immunogen promotes ocular surface inflammation, which causes plugging of meibomian gland secretion through neutrophil-produced aggNETs and leads to dry eye...
648
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

12.4K
Vital-dye enhanced fluorescence imaging (VFI) is a novel in vivo technique that combines high-resolution epithelial imaging with exogenous topical fluorescent contrast to highlight glandular morphology and delineate neoplasia (high grade dysplasia and cancer) in the distal...
12.4K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

1.1K
OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
1.1K
Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry05:15

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

9.2K
This protocol describes a method for the isolation of the mouse eyeball with eyelid, ocular surface, anterior and posterior segments in relatively intact...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: A Peculiar Pinguecula? A Surprising IgG4-Related Conjunctival Lesion.

Case reports in ophthalmology·2026
Same author

Injectable corneal endothelial cell therapy: recent progress, translational barriers, and future directions.

Frontiers in ophthalmology·2026
Same author

Real-world Safety Profile of Avacincaptad Pegol in the Management of Geographic Atrophy.

Ophthalmic surgery, lasers & imaging retina·2026
Same author

Artificial Intelligence for Diagnostic Guidance in Ocular Surface Disorders.

Journal of clinical medicine·2026
Same author

Imaging of Ocular Surface Lesions Using Anterior Segment Optical Coherence Tomography.

Clinical & experimental ophthalmology·2026
Same author

Prolonged stability of 1% 5-FU eye drops as topical chemotherapy for ocular surface squamous neoplasia.

The ocular surface·2026

Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.8K

Ocular Surface Squamous Neoplasia Masqueraders.

Carolina Mercado1, Carolina Parra-Rosas1, Carol L Karp1

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami.

Seminars in Ophthalmology
|January 19, 2026
PubMed
Summary

Ocular surface squamous neoplasia (OSSN) can mimic other eye lesions. Anterior segment optical coherence tomography (AS-OCT) helps differentiate OSSN from similar conditions, aiding diagnosis and treatment.

Keywords:
Kaposi sarcomaOCTOSSNOcular surface squamous neoplasiaPannusSalzmann’s nodular degenerationconjunctival lymphomaconjunctival melanomaconjunctival myxomaconjunctival nevusconjunctival papillomaoptical coherence tomographypterygium

More Related Videos

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.8K
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

12.4K

Related Experiment Videos

Last Updated: Jan 20, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.8K
Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.8K
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

12.4K

Area of Science:

  • Ophthalmology
  • Ocular Surface Disease
  • Diagnostic Imaging

Background:

  • Ocular surface squamous neoplasia (OSSN) presents diagnostic challenges due to its varied clinical appearance.
  • Numerous benign and malignant lesions can mimic OSSN, complicating accurate diagnosis.

Purpose of the Study:

  • To detail common ocular surface lesions that resemble OSSN.
  • To provide guidance on using anterior segment optical coherence tomography (AS-OCT) for accurate OSSN identification.

Main Methods:

  • Comprehensive review of ocular surface lesions categorized by etiology.
  • Critical assessment of clinical, histopathological, and AS-OCT imaging features.

Main Results:

  • Identified numerous OSSN mimics including pterygium, papilloma, and various tumors.
  • OSSN exhibits characteristic AS-OCT findings: hyperreflective thickened epithelium and sharp tissue transitions.
  • Distinct AS-OCT patterns differentiate OSSN from mimickers.

Conclusions:

  • Distinguishing OSSN from similar lesions is clinically challenging.
  • AS-OCT is a crucial non-invasive tool for reliable OSSN diagnosis.
  • AS-OCT supports informed management decisions and judicious use of biopsy.