Related Experiment Video
Updated: Apr 21, 2026
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
[Determination of von Willebrand factor multimers in Mexican population]
Edgar Hernández-Zamora1, Cesar Zavala-Hernández2, Martha Eva Viveros-Sandoval3
1Servicio de Genética, Instituto Nacional de Rehabilitación, Mexico.
Background:
Von Willebrand disease is an inherited disease in which the structure, function, and concentration of von Willebrand factor are altered, as well as the platelet von Willebrand factor endothelium interaction. In Mexico there are no epidemiological records of the disease. Only a few isolated studies have been reported from the clinical and hematological standpoint.
Methods:
We studied 155 Mexican Mestizos: 75 with presumptive diagnosis of von Willebrand disease, 15 with suspected diagnosis ofhemophilia A and 65 healthy donors (controls). Basic coagulation tests, special tests and classification test (analysis of multimeric composition) were carried out.
Results:
There were 15 patients with clinical diagnosis of hemophilia A, 75 patients with suspected von Willebrand disease of which 50 were diagnosed as the following types and subtypes: Type 1 (62%), Type 2 (22%) [subtypes: 2A (14%), 2B (2%), and 2N (6%)] and Type 3 (16%).
Conclusion:
It has been reported that analysis of von Willebrand factor is a method that meets the characteristics for the diagnosis of von Willebrand disease. It is necessary to implement this methodology to study and improve the specific diagnoses.
Insights
Von Willebrand disease (VWD) diagnosis in Mexico is challenging due to limited epidemiological data. This study identified VWD types 1, 2 (2A, 2B, 2N), and 3 in 50 patients, highlighting the need for improved diagnostic methods.
Area of Science:
- Hematology
- Genetics
- Epidemiology
Context:
- Von Willebrand disease (VWD) is a prevalent inherited bleeding disorder.
- Mexico lacks comprehensive epidemiological data on VWD.
- Previous studies focused on clinical and hematological aspects.
Purpose:
- To investigate the prevalence and types of Von Willebrand disease in Mexican Mestizos.
- To assess the utility of diagnostic tests for VWD.
Summary:
- A study of 155 Mexican Mestizos (75 with suspected VWD, 15 with suspected hemophilia A, 65 controls) utilized coagulation tests and multimeric analysis.
- Fifty patients were diagnosed with VWD: Type 1 (62%), Type 2 (22% - 2A, 2B, 2N), and Type 3 (16%).
- Fifteen patients were diagnosed with hemophilia A.
Impact:
- Establishes a baseline for VWD epidemiology in Mexico.
- Recommends the implementation of VWF analysis for accurate VWD diagnosis.
- Highlights the need for improved diagnostic strategies for VWD and related bleeding disorders.
