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Related Experiment Video

Updated: Apr 21, 2026

Analysis of Side Population in Solid Tumor Cell Lines

Analysis of Side Population in Solid Tumor Cell Lines

Published on: February 23, 2021

Warburg's effect on solid tumors.

Talal El Imad, Lara El Khoury, Abdallah Sassine Geara¹

¹Lebanese University, Beirut, Lebanon, .

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|November 15, 2014

Summary

This summary is machine-generated.

Malignancy-associated lactic acidosis, or Warburg's effect, can occur in solid tumors involving the liver. This condition has poor prognostic implications and requires careful management of metabolic acidosis and fluid therapy.

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Area of Science:

Oncology
Metabolic Medicine

Background:

Lactic acidosis results from an imbalance in lactate metabolism.
In cancer, it's often linked to hematologic malignancies via Warburg's effect.

Observation:

A 76-year-old male with hypertension and coronary artery disease presented with abdominal distension and lactic acidosis.
He was diagnosed with undifferentiated carcinoma involving the liver.
Lactic acidosis progressed, leading to death within 15 days.

Findings:

The patient's lactic acidosis was diagnosed as malignancy-associated type B, or Warburg's effect, unrelated to hypoxia or hemodynamic instability.
Warburg's effect in solid tumors, particularly liver involvement, indicates poor prognosis.

Implications:

Malignancy-associated lactic acidosis has significant negative prognostic implications.
Intravenous bicarbonate use for severe acidosis is controversial and potentially harmful.
Lactate-based IV fluids may increase metastasis risk in cancer patients.