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Grass-green urine from propofol infusion.
A B Pedersen1, T K Kobborg, J R Larsen
1Department of Anaesthesiology and Intensive Care, Silkeborg Regional Hospital, Silkeborg, Denmark.
Acta Anaesthesiologica Scandinavica
|November 15, 2014
Summary
Propofol infusion can cause rare green urine due to how the body processes the drug. This benign side effect occurs when the liver
Area of Science:
- Anesthesiology and Pharmacology
- Clinical Toxicology
Background:
- Propofol is a widely used intravenous anesthetic agent.
- Understanding its metabolic pathways is crucial for clinical practice.
Observation:
- A case of a 24-year-old male patient experiencing grass green urine discoloration during propofol infusion.
- The urine discoloration was noted as a potential side effect of the anesthetic.
Findings:
- Green urine associated with propofol infusion is a rare but benign clinical finding.
- This phenomenon occurs when propofol clearance surpasses hepatic elimination, leading to significant extrahepatic elimination.
- The specific metabolic byproducts or mechanisms responsible for the green hue are not fully elucidated but linked to altered propofol metabolism.
Implications:
- Clinicians should be aware of this rare side effect to avoid misdiagnosis or unnecessary investigations.
- Monitoring for urine color changes can be a subtle indicator of altered drug metabolism in patients receiving propofol.
- Further research may be warranted to understand the precise biochemical basis of propofol-induced urine discoloration.
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