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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

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Published on: June 22, 2012

Hemodynamics in the microcirculation and in microfluidics.

Toshihiro Omori¹, Yohsuke Imai, Kenji Kikuchi

¹Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Sendai, Miyagi, Japan, omori@pfsl.mech.tohoku.ac.jp.

Annals of Biomedical Engineering

|November 16, 2014

Summary

This review covers computational and experimental studies of blood flow in microcirculation and microfluidics, detailing red blood cell dynamics and cell adhesion models. It also explores microfluidic cell separation techniques for biomedical applications.

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Microfluidics in Assessing Platelet Function

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Published on: November 8, 2024

Area of Science:

Biomedical Engineering
Fluid Dynamics
Cellular Biology

Background:

Microcirculation hemodynamics is crucial for hemorheology and circulatory diseases.
Advancements in micro/nano-scale techniques are expanding hemodynamics research.
Understanding blood flow at micro-scales is vital for diagnosing and treating diseases.

Purpose of the Study:

To review recent computational and experimental studies of blood flow in microcirculation and microfluidics.
To highlight advancements in red blood cell dynamics and cell adhesion modeling.
To discuss microfluidic cell separation techniques and their biomedical applications.

Main Methods:

Computational fluid dynamics (CFD) for red blood cell (RBC) dynamics and white blood cell (WBC), platelet, and malaria-infected RBC adhesion.
Experimental techniques including optical microscopy, particle image velocimetry (PIV), and particle tracking velocimetry (PTV).
Microfluidic device development for cell separation and analysis.

Main Results:

Detailed review of RBC dynamics from single-cell to multi-cellular flows.
Overview of computational models for cell adhesion to vascular walls.
Demonstration of microfluidic cell separation for diagnostic applications (e.g., cancer detection).

Conclusions:

Microfluidics and advanced computational methods offer powerful tools for studying microcirculation hemodynamics.
Cell adhesion models are essential for understanding cellular functions in vascular environments.
Microfluidic cell separation holds significant promise for future biomedical diagnostics and research.