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Physicochemical and formulation developability assessment for therapeutic peptide delivery--a primer.
Annette Bak1, Dennis Leung, Stephanie E Barrett
1Discovery Pharmaceutical Sciences, Merck & Co, Kenilworth, New Jersey, USA, annette_bak@merck.com.
The AAPS Journal
|November 16, 2014
Summary
Peptides offer therapeutic promise but face delivery challenges. This review explores peptide properties, formulation strategies, and diverse administration routes to advance peptide drug development.
Area of Science:
- Pharmaceutical Science
- Drug Delivery
- Biotechnology
Background:
- Peptides are crucial endogenous ligands regulating biological processes.
- They hold significant therapeutic potential for various severe diseases.
- However, peptide-based therapeutics encounter substantial drug delivery challenges.
Purpose of the Study:
- To review the physicochemical, biophysical, and biopharmaceutical properties of peptides relevant to drug development.
- To discuss various peptide drug delivery modalities, focusing on parenteral and alternative routes.
- To highlight formulation techniques for overcoming peptide developability obstacles.
Main Methods:
- Literature review of peptide properties and drug delivery strategies.
- Analysis of formulation techniques for peptide pharmaceuticals.
- Examination of characterization methods for oral peptide delivery.
Main Results:
- Parenteral administration is the most common route for peptide drugs.
- Alternative routes like inhalation, transdermal, and intranasal offer patient preference.
- Specific formulation strategies can mitigate developability issues for peptide delivery.
Conclusions:
- Understanding peptide properties is key to successful drug development.
- Innovative formulation and delivery approaches are essential for peptide therapeutics.
- Advancing pharmaceutical science will enhance the development of this promising drug class.
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