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CMPD: cancer mutant proteome database.

Po-Jung Huang1, Chi-Ching Lee2, Bertrand Chin-Ming Tan3

  • 1Bioinformatics Core Laboratory, Chang Gung University, Taoyuan 333, Taiwan Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.

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Summary
This summary is machine-generated.

Whole-exome sequencing identifies genetic alterations linked to diseases. A new database, CMPD, archives mutant protein sequences from genomic data, aiding biomarker discovery and translational research.

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Area of Science:

  • Genomics
  • Proteomics
  • Bioinformatics

Background:

  • Whole-exome sequencing (WES) is a cost-effective method for identifying genetic alterations associated with diseases and cancer.
  • Large-scale sequencing projects have generated extensive coding variant data, necessitating integration with proteomic information.
  • Current resources lack comprehensive databases for mutant protein sequences derived from large-scale genomic data.

Purpose of the Study:

  • To address the need for integrating genomic and proteomic datasets.
  • To create a centralized repository for mutant protein sequences corresponding to genomic alterations.
  • To facilitate the identification and validation of potential cancer biomarkers and support translational medicine.

Main Methods:

  • Collected over 2 million genetic alterations from various sources.
  • Developed the CMPD database (http://cgbc.cgu.edu.tw/cmpd) to archive mutant protein sequences.
  • Facilitated cross-platform integration of sequencing information and proteome data.

Main Results:

  • Established CMPD, a comprehensive database of mutant protein sequences linked to genetic alterations.
  • The database contains over 2 million genetic alterations, providing a rich resource for research.
  • Enabled the examination of potential cancer biomarkers and identification of mutated proteins.

Conclusions:

  • CMPD serves as a critical bridge between genomic and proteomic data.
  • The database is an invaluable resource for translational medicine research and biomarker discovery.
  • Facilitates the identification of mutated proteins encoded by genes with identified alterations.