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Substance P receptors in the human spinal cord: decrease in amyotrophic lateral sclerosis.

M M Dietl1, M Sanchez, A Probst

  • 1Preclinical Research, Sandoz Ltd., Basel, Switzerland.

Brain Research
|March 27, 1989
PubMed
Summary
This summary is machine-generated.

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Substance P receptors are found on motor neurons in the human spinal cord. Their reduction in amyotrophic lateral sclerosis suggests a role for substance P in motor neuron function.

Area of Science:

  • Neuroscience
  • Neuropharmacology
  • Spinal Cord Research

Background:

  • Substance P is a neuropeptide involved in pain and motor control.
  • Understanding substance P receptor distribution is crucial for neurological research.

Purpose of the Study:

  • To map the distribution of substance P receptors in the human spinal cord.
  • To investigate the role of substance P in motor neuron function and diseases like ALS.

Main Methods:

  • Autoradiography using [125I]Bolton-Hunter substance P ligand.
  • Radioimmunohistochemistry to localize substance P-like immunoreactivity.
  • Analysis of postmortem spinal cord tissue from control subjects and ALS patients.

Main Results:

Related Experiment Videos

  • Substance P receptors are highly concentrated in the substantia gelatinosa, intermediolateral cell column, and ventral horn motor neurons.
  • Substance P-like immunoreactivity is concentrated in the superficial dorsal horn and intermediolateral cell columns.
  • A significant reduction in substance P binding was observed in the ventral horn of ALS patients, correlating with motor neuron loss.

Conclusions:

  • Substance P receptors are postsynaptically located on human spinal cord motor neurons.
  • Substance P likely plays a role in motor neuron function.
  • Altered substance P receptor binding may be implicated in the pathophysiology of amyotrophic lateral sclerosis.